![]() ![]() Miyagawa T, Tokunaga K: Genetics of narcolepsy. Capittini C, De Silvestri A, Terzaghi M, et al: Correlation between HLA-DQB1*06:02 and narcolepsy with and without cataplexy: approving a safe and sensitive genetic test in four major ethnic groups. Bassetti CLA, Adamantidis A, Burdakov D, et al: Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment. Andlauer O, Moore H 4th, Hong SC, et al: Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy Sleep 2012 Sep 1 35(9):1247-1255FĤ. Doctor Holding In Hand Cataplexy Narcolepsy - Download From Over 177 Million High Quality Stock Photos, Images, Vectors, Stock Video. Chabas D, Taheri S, Renier C, Mignot E: The genetics of narcolepsy. Mignot E, Lin X, Arrigoni J, et al: DQB1*0602 and DQB1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and Black Americans. However, its absence does not rule-out narcolepsy without cataplexy (narcolepsy type 2).ġ. A more reliable approach would be to consider that, in an appropriate patient who has cataplexy, the absence of the strongly associated DQB1*06:02 provides good evidence that the patient does not have narcolepsy. It must also be clearly understood that about 25% of normal people have this gene.īecause DQB1*06:02 is present in the normal population, no test for an HLA gene constitutes a test for narcolepsy. Cataplexy is defined as a sudden episode of muscle weakness triggered by emotional factors, most often in the context of positive emotions (such as laughter, having a good hand at a card game, the pull of the fishing rod with a biting fish, the perfect hit at a baseball game) and less frequently by negative emotions (most typically anger or frustration). ![]() DQB1*06:02 is found in 90% to 95% of African American, White, and Japanese patients with narcolepsy who also have cataplexy (narcolepsy type 1), but only in 45% to 50% of patients with narcolepsy without cataplexy (narcolepsy type 2). Studies have identified DQB1*06:02 as a useful marker of narcolepsy. Cataplexy (weakness precipitated by emotions, especially laughter) is present in 64% to 79% of patients with narcolepsy. It is characterized by excessive daytime somnolence and abnormal rapid eye movement (REM) sleep. Narcolepsy is a neurological condition affecting about 0.02% of African American, White, and Japanese individuals. Michigan Department of Health & Human Services.Centers for Medicare and Medicaid Services.Please call 616.774.7721 for specimen pick up ![]()
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